BRIGHTER 3D ACTIVATE SKIN
Although various cell types within the skin can carry out this transformation locally, the conversion takes place primarily in the liver. The initial photosynthesis produces vitamin D 3, most of which undergoes additional transformations, starting with the production of 25-hydroxyvitamin D (25D), the major form of vitamin D circulating in the bloodstream and the form that is routinely measured to determine a person’s vitamin D status. For most white people, a half-hour in the summer sun in a bathing suit can initiate the release of 50,000 IU (1.25 mg) vitamin D into the circulation within 24 hours of exposure this same amount of exposure yields 20,000–30,000 IU in tanned individuals and 8,000–10,000 IU in dark-skinned people. The efficiency of production depends on the number of UVB photons that penetrate the skin, a process that can be curtailed by clothing, excess body fat, sunscreen, and the skin pigment melanin. Unlike other essential vitamins, which must be obtained from food, vitamin D can be synthesized in the skin through a photosynthetic reaction triggered by exposure to UVB radiation. As for what constitutes “excessive” UVR exposure, there is no one-size-fits-all answer, says Lucas: “‘Excessive’ really means inappropriately high for your skin type under a particular level of ambient UVR.” At least 1,000 different genes governing virtually every tissue in the body are now thought to be regulated by 1,25-dihydroxyvitamin D 3 (1,25D), the active form of the vitamin, including several involved in calcium metabolism and neuromuscular and immune system functioning.Īlthough most of the health-promoting benefits of sun exposure are thought to occur through vitamin D photosynthesis, there may be other health benefits that have gone largely overlooked in the debate over how much sun is needed for good health. The best-known benefit of sunlight is its ability to boost the body’s vitamin D supply most cases of vitamin D deficiency are due to lack of outdoor sun exposure. This burden subsumes major disorders of the musculoskeletal system and possibly an increased risk of various autoimmune diseases and life-threatening cancers. In contrast, the same WHO report noted that a markedly larger annual disease burden of 3.3 billion DALYs worldwide might result from very low levels of UVR exposure. Therefore, when measuring by DALYs, these diseases incur a relatively low disease burden despite their high prevalence. Coauthor Robyn Lucas, an epidemiologist at the National Centre for Epidemiology and Population Health in Canberra, Australia, explains that many diseases linked to excessive UVR exposure tend to be relatively benign-apart from malignant melanoma-and occur in older age groups, due mainly to the long lag between exposure and manifestation, the requirement of cumulative exposures, or both. DALYs measure how much a person’s expectancy of healthy life is reduced by premature death or disability caused by disease. However, excessive UVR exposure accounts for only 0.1% of the total global burden of disease in disability-adjusted life years (DALYs), according to the 2006 World Health Organization (WHO) report The Global Burden of Disease Due to Ultraviolet Radiation. Excessive sun exposure can also cause cataracts and diseases aggravated by UVR-induced immunosuppression such as reactivation of some latent viruses. Both forms can damage collagen fibers, destroy vitamin A in skin, accelerate aging of the skin, and increase the risk of skin cancers. Sunburn is caused by too much UVB radiation this form also leads to direct DNA damage and promotes various skin cancers. UVA radiation (95–97% of the UVR that reaches Earth’s surface) penetrates deeply into the skin, where it can contribute to skin cancer indirectly via generation of DNA-damaging molecules such as hydroxyl and oxygen radicals. Most public health messages of the past century have focused on the hazards of too much sun exposure.
Today’s scientists have come to a similarly dichotomous recognition that exposure to the ultraviolet radiation (UVR) in sunlight has both beneficial and deleterious effects on human health. For the ancient Greeks and Romans, Apollo was the god of medicine and healing as well as of sun and light-but Apollo could bring sickness as well as cure. Each day, Apollo’s fiery chariot makes its way across the sky, bringing life-giving light to the planet.
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